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Isolation and characterization of new cannabis constituents from a high potency variety.

Radwan MM, Ross SA, Slade D, Ahmed SA, Zulfiqar F, Elsohly MA

National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, University, MS, USA.

Phytochemical investigation of a high potency variety of CANNABIS SATIVA L. resulted in the isolation of six new metabolites, (+/-)-6,7- TRANS-epoxycannabigerolic acid ( 2), (+/-)-6,7- CIS-epoxycannabigerolic acid ( 3), (+/-)-6,7- CIS-epoxycannabigerol ( 4), (+/-)-6,7- TRANS-epoxycannabigerol ( 5), 5'-methyl-4-pentylbiphenyl-2,2',6-triol ( 7), and 7-methoxycannabispirone ( 8), along with seven known compounds namely, cannabigerolic acid ( 1), 5'-methoxycannabigerolic acid ( 6), cannabispirone ( 9), beta-cannabispiranol ( 10), dehydrocannabifuran ( 11), cannflavin B ( 12) and cannabigerol ( 13). The antimicrobial as well as the antileishmanial activities were investigated. CBG:cannabigerol CBD:cannabidiol FID:flame ionization detector Delta (9)-THC:Delta (9)-tetrahydrocannabinol VLC:vacuum liquid chromatography.

Published 17 March 2008 in Planta Med, 74(3): 267-72.
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