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Marijuana Research Today is a free monthly online journal that collates and summarizes the latest research about Marijuana, including details on benefits, cancer, effects, uses, addiction.


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How high: Quantity as a predictor of cannabis-related problems.

Walden N, Earleywine M

Department of Psychology, University at Albany, State University of New York, 1400 Washington Ave,, SS369, Albany, New York, 12222, USA. mearleywine@albany.edu.

ABSTRACT: BACKGROUND: Research on cannabis use has emphasized frequency as a predictor of problems. Studies of other drugs reveal that frequency relates to psychological and physiological outcomes, but quantity also plays an important role. In the study of cannabis, quantity has been difficult to assess due to the wide range of products and means of consumption. METHODS: The present study introduces three new measures of quantity, and examines their contribution to cannabis-related problems. Over 5,900 adults using cannabis once or more per month completed an internet survey that inquired about use, dependence, social problems and respiratory health. In addition to detailing their frequency of cannabis use, participants also reported three measures of quantity: number of quarter ounces consumed per month, usual intensity of intoxication, and maximum intensity of intoxication. RESULTS: Frequency of use, monthly consumption, and levels of intoxication predicted respiratory symptoms, social problems and dependence. What is more, each measure of quantity accounted for significant variance in outcomes after controlling for the effects of frequency. CONCLUSION: These findings indicate that quantity is an important predictor of cannabis-related outcomes, and that the three quantity measures convey useful information about use.

Published 25 June 2008 in Harm Reduct J, 5: 20.
Full-text of this article is available online (may require subscription).


Articles on Marijuana published 24 June 2008:

Beta-caryophyllene is a dietary cannabinoid.   Proc Natl Acad Sci U S A.

The psychoactive cannabinoids from Cannabis sativa L. and the arachidonic acid-derived endocannabinoids are nonselective natural ligands for cannabinoid receptor type 1 (CB(1)) and CB(2) receptors. Although the CB(1) receptor is responsible for the psychomodulatory effects, activation of the CB(2) receptor is a potential therapeutic strategy for the treatment of inflammation, pain, atherosclerosis, and osteoporosis. Here, we report that the widespread plant volatile (E)-beta-caryophyllene ... [Abstract] [Full-text]

Schizophrenia, "Just the Facts" What we know in 2008. 2. Epidemiology and etiology.   Schizophr Res, 102(1): 1-18.

Although we have studied schizophrenia as a major disease entity over the past century, its causes and pathogenesis remain obscure. In this article, we critically review genetic and other epidemiological findings and discuss the insights they provide into the causes of schizophrenia. The annual incidence of schizophrenia averages 15 per 100,000, the point prevalence averages approximately 4.5 per population of 1000, and the risk of developing the illness over one's lifetime averages 0.7%. ... [Abstract] [Full-text]


Articles on Marijuana published 23 June 2008:

Adolescents' self-defined tobacco use status, marijuana use, and tobacco dependence.   Addict Behav.

AIMS: To examine differences in tobacco use and dependence between adolescents who are and are not marijuana users. DESIGN: Cross-sectional analysis of existing survey data. PARTICIPANTS: Data were obtained from 7440 adolescents who completed the British Columbia Youth Survey of Smoking and Health II (BCYSOSH-II), a school based survey conducted in 2004. MEASURES: Responses to demographic, current smoking, alcohol use, self-defined tobacco and marijuana use status questions, perceived physical ... [Abstract] [Full-text]

Differences in regional blood volume during a 28-day period of abstinence in chronic cannabis smokers.   Eur Neuropsychopharmacol.

Cerebral blood volume (CBV) studies have provided important insight into the effects of illicit substances such as cannabis. The present study examined changes in regional blood volume in the frontal and temporal lobe, and the cerebellum during 28 days of supervised abstinence from cannabis. Dynamic susceptibility contrast MRI (DSCMRI) data were collected on 15 current, long-term cannabis users between 6 and 36 h after the subjects' last reported cannabis use (Day 0), and again after 7 and 28 ... [Abstract] [Full-text]


Articles on Marijuana published 20 June 2008:

Substance Use Among Women: Associations with Pregnancy, Parenting, and Race/Ethnicity.   Matern Child Health J.

Objective To examine the association of pregnancy and parenting (0- to 2-year-old child) statuses with past 30-day use of alcohol, cigarettes and marijuana, psychotherapeutics and cocaine among American women aged 18-44, overall and by race/ethnicity. Methods Five years of data (2002-2006) from the National Survey on Drug Use and Health (NSDUH) were pooled. Binary logistic regression analyses stratified by race/ethnicity were performed to examine the relationships adjusting for age, marital ... [Abstract] [Full-text]

Cannabinoids inhibit the respiration of human sperm.   Fertil Steril.

OBJECTIVE: To investigate the effects of the psychotropic compounds Delta(9)-tetrahydrocannabinol (Delta(9)-THC) and Delta(8)-tetrahydrocannabinol (Delta(8)-THC) on sperm mitochondrial O(2) consumption (respiration). SETTING: State University of New York Upstate Medical University, Syracuse, New York. PATIENT(S): Forty-one men who visited the andrology laboratory for fertility evaluation. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): A phosphorescence analyzer that measures O(2) concentration ... [Abstract] [Full-text]

Decision Making in Alcohol Dependence: Insensitivity to Future Consequences and Comorbid Disinhibitory Psychopathology.   Alcohol Clin Exp Res.

Background: Alcohol dependence (AD) is often comorbid with other disinhibitory disorders that are characterized by poor decision making and evidenced by disadvantageous strategies on laboratory tasks such as the Iowa Gambling Task (IGT). In this study, a variant of the IGT is used to examine specific mechanisms that may account for poor decision making on the task in AD both with and without comorbid psychopathology. Methods: The community sample (n = 428) included 134 young adult subjects with ... [Abstract] [Full-text]


Articles on Marijuana published 19 June 2008:

Simultaneous determination of amphetamine-type stimulants and cannabinoids in fingernails by gas chromatography-mass spectrometry.   Arch Pharm Res, 31(6): 805-813.

A gas chromatography-mass spectrometric (GC-MS) method was developed and validated for the simultaneous detection and quantification of four amphetamine-type stimulants (amphetamine (AP), methamphetamine (MA), 3,4-methylenedioxyamphetamine (MDA) and 3,4-methylenedioxymethamphetamine (MDMA)) and two cannabinoids (Delta(9)-tetrahydrocannabinol (Delta(9)-THC) and 11-nor-Delta(9)-tetrahydrocannabinol-9-carboxylic acid (THCCOOH)) in fingernails. Fingernail clippings (30 mg) were washed with ... [Abstract] [Full-text]


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